In addition to regulating the LIMK pathway PAKs PAK and
In addition to regulating the LIMK1 pathway, PAKs (PAK1 and PAK3) have been shown to modulate the ATPase activity of myosin light chain (MLC) via phosphorylation of Ser19 in hippocampal dendritic spines . MLC activity guarantees long-term stability of GW3965 filaments by providing the mechanica
In C BL mice activation of
In C57BL/6 mice, activation of FXR by the agonist GW4064 increased SR-BI mRNA and protein expression and increased fasting plasma corticosterone levels after overnight fasting . As described before, the receptor SR-BI regulates transport of cholesteryl esters from HDL and LDL  into the adren
2-NBDG Interestingly the C domain is also
Interestingly, the C1 domain is also known to harbor a large number of pathogenic HCM-causing mutations , and most mutations implicated in HCM in the C1 domain are clustered towards the C-terminal end . One such single amino 2-NBDG mutation located in the C terminal end of the C1 domain is
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Discussion The current model of the pathological mechanism underlying AGel amyloidosis is mostly based on studies performed on the D187N-mutated protein and experiments conducted in vitro and in vivo on transgenic animals expressing this variant [15,16,48]. Results obtained with D187N likely also apply to the later discovered Danish variant (D187Y), although some differences were reported .